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The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics

Yirmiya, Nurit and Charman, Tony (2010) The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 51 (4). pp. 432-458. ISSN 0021-9630

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Abstract

Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the ‘core’ disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and ‘high risk’ sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. Whilst no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate the early presentation and even ‘prevent’ emergence of the full syndrome.

Item Type: Article
Additional Information: The definitive version is available at www3.interscience.wiley.com
Divisions: IOE Departments > Departments > Psychology and Human Development
Depositing User: IOE Repository Editor (2)
Date Deposited: 13 May 2010 10:15
Last Modified: 14 Oct 2013 23:06
URI: http://eprints.ioe.ac.uk/id/eprint/4444
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