Yirmiya, Nurit and Charman, Tony (2010) The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 51 (4). pp. 432-458. ISSN 0021-9630
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Abstract
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the ‘core’ disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and ‘high risk’ sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. Whilst no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate the early presentation and even ‘prevent’ emergence of the full syndrome.
| Item Type: | Article |
|---|---|
| Additional Information: | The definitive version is available at www3.interscience.wiley.com |
| Divisions: | IOE Departments > Departments > Psychology and Human Development |
| Depositing User: | IOE Repository Editor (2) |
| Date Deposited: | 13 May 2010 10:15 |
| Last Modified: | 01 Jun 2013 23:06 |
| URI: | http://eprints.ioe.ac.uk/id/eprint/4444 |
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